The metabolic syndrome can be detected in advance by testing fasting insulin levels. Fasting insulin levels could be found increased even when blood glucose levels may be normal. The lipid profile may indicate elevated TG and cholesterol levels. The normal TG/HDL ratio should be less than 2 and LDL/HDL ratio should be less than 3.5. The lipoproteins which carry various types of lipids in blood are attacked by elevated glucose levels and they become glycolated. Such LDL molecules are prone to oxidation which have affinity to get deposited under the endothelial cells of blood levels which initiates inflammation and subsequent atherosclerosis. The state of inflammation of the arteries can be detected by CRP ('C' reactive protein). Serum homocysteine levels, which should be as minimum as possible, indicate state of hardening of the arteries.

HOW DOES METABOLIC SYNDROME START?

How atheroscerosis starts?